Psilocybin mushrooms
Common Names: Psilocybin, The
Psychoactive Effects
Positive Effects
- Euphoria
Neutral Effects
- Visual hallucinations
- Time distortion
- Synesthesia
- Altered thought patterns
- Enhanced sensory perception
- Ego dissolution
Negative Effects
- Anxiety
- Depression
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Oral | 0.5-1 g dried | 1-2 g dried | 2-3.5 g dried | 3.5-5 g dried | 5+ g dried |
Duration
| Phase | Duration |
|---|---|
| Onset | 30-60 minutes |
| Peak | 2-4 hours |
| Total | 4-8 hours |
| After effects | 2-4 hours |
Pharmacology
Mechanism of Action: Psilocybin is a prodrug for psilocin, which acts as a partial agonist at serotonin 5-HT2A receptors, similar to other classical psychedelics.
Metabolism: Metabolized in the liver by alkaline phosphatase to form psilocin, which is then further metabolized by CYP2D6 and CYP3A4 enzymes.
Half-life: Approximately 2-3 hours, with effects typically lasting 4-8 hours.
Bioavailability: ~70% when taken orally, with peak plasma concentrations reached within 1-2 hours.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Nichols, D. E. (2016). Psychedelics. Pharmacological Reviews, 68(2), 264-355.
- • Carhart-Harris, R. L., et al. (2016). Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. The Lancet Psychiatry, 3(7), 619-627.
- • Information compiled from PsychonautWiki