Nicotine
Common Names: Pituri, Aboriginal, Australians, At, After
Psychoactive Effects
Positive Effects
- Euphoria
Neutral Effects
- Increased alertness
- Enhanced focus
- Reduced anxiety
- Increased heart rate
- Pupil dilation
- Dry mouth
Negative Effects
- Anxiety
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Smoked | 0.5-1 mg | 1-3 mg | 3-6 mg | 6-10 mg | 10+ mg |
Duration
| Phase | Duration |
|---|---|
| Onset | Immediate (smoked) |
| Peak | 5-10 minutes |
| Total | 30-60 minutes |
| After effects | 1-2 hours |
Pharmacology
Mechanism of Action: Nicotine acts as an agonist at nicotinic acetylcholine receptors (nAChRs), particularly α4β2 and α7 subtypes, increasing dopamine, norepinephrine, and acetylcholine release.
Metabolism: Metabolized in the liver primarily by CYP2A6 enzyme. Major metabolite is cotinine.
Half-life: Approximately 2 hours, with effects typically lasting 30-60 minutes.
Bioavailability: ~90% when smoked, ~30% when taken orally due to first-pass metabolism.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Benowitz, N. L. (2009). Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. Annual Review of Pharmacology and Toxicology, 49, 57-71.
- • Dani, J. A., & De Biasi, M. (2001). Cellular mechanisms of nicotine addiction. Pharmacology Biochemistry and Behavior, 70(4), 439-446.
- • Information compiled from PsychonautWiki