Mescaline
Common Names: Trimethoxyphenethylamine, It, Lophophora, San, Pedro
Psychoactive Effects
Positive Effects
- Euphoria
Neutral Effects
- Visual hallucinations
- Time distortion
- Enhanced colors
- Geometric patterns
- Altered body perception
- Enhanced tactile sensations
Negative Effects
- Information not available
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Oral | 100-200 mg | 200-400 mg | 400-800 mg | 800-1200 mg | 1200+ mg |
Duration
| Phase | Duration |
|---|---|
| Onset | 60-120 minutes |
| Peak | 4-6 hours |
| Total | 8-12 hours |
| After effects | 4-8 hours |
Pharmacology
Mechanism of Action: Mescaline acts as a partial agonist at serotonin 5-HT2A and 5-HT2C receptors, similar to other phenethylamine psychedelics.
Metabolism: Metabolized in the liver primarily by CYP2D6 and CYP3A4 enzymes. Major metabolites include 3,4,5-trimethoxyphenylacetic acid.
Half-life: Approximately 6-8 hours, with effects typically lasting 8-12 hours.
Bioavailability: ~60% when taken orally, with peak plasma concentrations reached within 2-3 hours.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Nichols, D. E. (2016). Psychedelics. Pharmacological Reviews, 68(2), 264-355.
- • Shulgin, A. T., & Shulgin, A. (1991). PiHKAL: A Chemical Love Story. Transform Press.
- • Information compiled from PsychonautWiki