LSD
Common Names: Lysergic, Lysergide, LSD-25, Lucy, Acid
Psychoactive Effects
Positive Effects
- Euphoria
- Energy
Neutral Effects
- Time distortion
- Visual hallucinations
- Synesthesia
- Altered thought patterns
- Enhanced sensory perception
- Ego dissolution
Negative Effects
- Anxiety
- Paranoia
- Dysphoria
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Oral | 20-30 μg | 30-75 μg | 75-150 μg | 150-300 μg | 300+ μg |
Duration
| Phase | Duration |
|---|---|
| Onset | 30-90 minutes |
| Peak | 2-4 hours |
| Total | 8-12 hours |
| After effects | 6-12 hours |
Pharmacology
Mechanism of Action: LSD acts as a partial agonist at serotonin 5-HT2A receptors, with additional activity at 5-HT1A, 5-HT2B, 5-HT2C, and dopamine D2 receptors.
Metabolism: Metabolized in the liver primarily by CYP3A4 and CYP2D6 enzymes. Major metabolites include 2-oxo-3-hydroxy-LSD and various hydroxylated derivatives.
Half-life: Approximately 3-5 hours, with effects typically lasting 8-12 hours.
Bioavailability: ~70% when taken orally, with peak plasma concentrations reached within 1-2 hours.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Nichols, D. E. (2016). Psychedelics. Pharmacological Reviews, 68(2), 264-355.
- • Halberstadt, A. L., & Geyer, M. A. (2018). Effect of hallucinogens on unconditioned behavior. Current Topics in Behavioral Neurosciences, 36, 159-199.
- • Carhart-Harris, R. L., et al. (2016). Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences, 113(17), 4853-4858.
- • Information compiled from PsychonautWiki