Kratom
Common Names: Mitragyna, South, East, Asia, The
Psychoactive Effects
Positive Effects
- Euphoria
Neutral Effects
- Pain relief
- Relaxation
- Increased energy
- Reduced anxiety
- Pupil constriction
- Constipation
Negative Effects
- Anxiety
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Oral | 1-3 g | 3-6 g | 6-12 g | 12-20 g | 20+ g |
Duration
| Phase | Duration |
|---|---|
| Onset | 15-30 minutes |
| Peak | 1-2 hours |
| Total | 4-6 hours |
| After effects | 6-12 hours |
Pharmacology
Mechanism of Action: Kratom contains mitragynine and 7-hydroxymitragynine, which act as partial agonists at mu-opioid receptors and antagonists at kappa-opioid receptors.
Metabolism: Metabolized in the liver primarily by CYP3A4 and CYP2D6 enzymes. Major metabolites include mitragynine pseudoindoxyl.
Half-life: Approximately 3-4 hours, with effects typically lasting 4-6 hours.
Bioavailability: ~60% when taken orally, with peak plasma concentrations reached within 1-2 hours.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Kruegel, A. C., & Grundmann, O. (2018). The medicinal chemistry and neuropharmacology of kratom: a preliminary discussion of a promising medicinal plant and analysis of its potential for abuse. Neuropharmacology, 134, 108-120.
- • Hassan, Z., et al. (2013). From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction. Neuroscience & Biobehavioral Reviews, 37(2), 138-151.
- • Information compiled from PsychonautWiki