Fentanyl
Common Names: Fentanil, Sublimaze, Actiq, Durogesic, Duragesic
Psychoactive Effects
Positive Effects
- Euphoria
- Happiness
Neutral Effects
- Euphoria
- Pain relief
- Sedation
- Respiratory depression
- Constipation
- Pupil constriction
Negative Effects
- Depression
- Anxiety
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Intranasal | 0.02-0.05 mg | 0.05-0.1 mg | 0.1-0.2 mg | 0.2-0.4 mg | 0.4+ mg |
Duration
| Phase | Duration |
|---|---|
| Onset | 2-5 minutes |
| Peak | 10-20 minutes |
| Total | 1-2 hours |
| After effects | 2-4 hours |
Pharmacology
Mechanism of Action: Fentanyl acts as a potent agonist at mu-opioid receptors, producing analgesia, euphoria, and respiratory depression.
Metabolism: Metabolized in the liver primarily by CYP3A4 enzyme. Major metabolites include norfentanyl and despropionylfentanyl.
Half-life: Approximately 2-4 hours, with effects typically lasting 1-2 hours.
Bioavailability: ~70% when insufflated, ~100% when administered intravenously.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Pasternak, G. W. (2014). Opioids and their receptors: are we there yet? Neuropharmacology, 76, 198-203.
- • Volkow, N. D., et al. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4), 363-371.
- • Information compiled from PsychonautWiki