Cocaine
Common Names: It, Erythroxylum, South, America, The
Psychoactive Effects
Positive Effects
- Euphoria
Neutral Effects
- Increased energy
- Enhanced focus
- Reduced appetite
- Increased heart rate
- Pupil dilation
- Euphoria
Negative Effects
- Anxiety
- Depression
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Insufflated | 5-15 mg | 15-30 mg | 30-60 mg | 60-100 mg | 100+ mg |
| Oral | 50-100 mg | 100-200 mg | 200-400 mg | 400-600 mg | 600+ mg |
Duration
| Phase | Duration |
|---|---|
| Onset | 1-3 minutes (insufflated) |
| Peak | 15-30 minutes |
| Total | 30-60 minutes |
| After effects | 1-3 hours |
Pharmacology
Mechanism of Action: Cocaine acts as a reuptake inhibitor of dopamine, norepinephrine, and serotonin by binding to their respective transporters, preventing reuptake and increasing extracellular concentrations.
Metabolism: Metabolized in the liver primarily by plasma esterases and CYP3A4 enzymes. Major metabolites include benzoylecgonine and ecgonine methyl ester.
Half-life: Approximately 1-2 hours, with effects typically lasting 30-60 minutes.
Bioavailability: ~30% when insufflated, ~25% when taken orally, and ~100% when administered intravenously.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Volkow, N. D., et al. (2016). Neurobiologic advances from the brain disease model of addiction. New England Journal of Medicine, 374(4), 363-371.
- • Karch, S. B. (2009). Karch's Pathology of Drug Abuse. CRC Press.
- • Goldstein, R. A., et al. (2009). Medical toxicology of drug abuse: synthesized chemicals and psychoactive plants. John Wiley & Sons.
- • Information compiled from PsychonautWiki