CBD
Common Names: Cannabidiol, Epidiolex, It, It, THC
Psychoactive Effects
Positive Effects
- Information not available
Neutral Effects
- Relaxation
- Reduced anxiety
- Pain relief
- Anti-inflammatory effects
- Improved sleep
- Reduced stress
Negative Effects
- Anxiety
Dosage Guidelines
| Route | Threshold | Light | Common | Strong | Heavy |
|---|---|---|---|---|---|
| Oral | 5-10 mg | 10-25 mg | 25-50 mg | 50-100 mg | 100+ mg |
Duration
| Phase | Duration |
|---|---|
| Onset | 30-60 minutes |
| Peak | 2-4 hours |
| Total | 6-8 hours |
| After effects | 8-12 hours |
Pharmacology
Mechanism of Action: CBD acts as a negative allosteric modulator at CB1 receptors and may affect serotonin, TRPV1, and PPAR receptors.
Metabolism: Metabolized in the liver primarily by CYP3A4 and CYP2C19 enzymes. Major metabolites include 7-hydroxy-CBD and 7-carboxy-CBD.
Half-life: Approximately 18-32 hours, with effects typically lasting 6-8 hours.
Bioavailability: ~20% when taken orally due to first-pass metabolism, with peak plasma concentrations reached within 1-2 hours.
Risks and Harm Reduction
⚠️ Important: Always practice harm reduction. Start with low doses, test your substances, and ensure a safe set and setting. Never use alone.
Legal Status
Disclaimer: Legal status varies by jurisdiction and may change. This information is for educational purposes only.
References
- • Pertwee, R. G. (2008). The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin. British Journal of Pharmacology, 153(2), 199-215.
- • Blessing, E. M., et al. (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12(4), 825-836.
- • Information compiled from PsychonautWiki